Delphinium denudatum, Nirvisha

Delphinium denudatum Wall
Family: Ranunculaceae

• Common name: Jadwar
• Arabic: عائق مكتشف
• Hindi: Jadwar, Judwar, Nirbishi, Nirbisi, Nirvisi
• Kannada: nirvishi
• Malayalam: nirvasi
• Marathi: nirvishi
• Nepali: निरबिशी Nirbishi
• Sanskrit: apavisha, avisa, avisha, nirvisa, nirvisha
• Tamil: nirbasi
• Urdu: jadwa, jadwaar, Khataai, Maatiryaaq.

Used in Ayurveda and Unani. Whole plant juice applied on cuts for immediate relief and healing. Roots bitter, febrifuge, anthelmintic,  diuretic,  antiinflammatory,  carminative,  vulnerary, stimulant, alterative, aphrodisiac, cardiotonic, tonic, cooling,  digestive,  used  in  fever,  insanity,  jaundice,  strangury, obesity, skin diseases, ulcers, respiratory complaints, catarrh, cold, cough, asthma, toothache; dried roots chewed as  stimulant;  a  water-paste  of  the  roots  applied  on  ulcers; roots  powder  for  killing  lice;  roots  pressed  between  teeth to get relief from toothache. Seeds used for the treatment of skin eruptions. Veterinary medicine, roots for killing ticks and lice in domestic animals; antidote in case of poisoning caused by Aconitum ferox. [CRC World Dictionary of Medicinal and Poisonous Plants]

Root—astringent, vulnerary, deobstruent, alterative. Used for painful piles, muscular atrophy, gout and as a nervine tonic. Also used as an adulterant for aconite. [Indian Medicinal Plants An Illustrated Dictionary]

39 Published articles of Delphinium denudatum
1.    Acute toxicity and antinociceptive properties of Delphinium denudatum Zafar, S., M.A. Ahmad, and T.A. Siddiquiz, Pharmaceutical Biology, 2003. 41(7): p. 542-545.
2.    Alkaloids from Delphinium denudatum Nazar, S., Jour Sci and Indust Res, 1961. 20((1)): p. 39-39.
3.    Anticonvulsant, a.a.m.e.a.o.D.d.a.P.e.N., Q. and M.A. Jafri, European Neuropsychopharmacology, 2005. 15: p. S638-S638.
4.    Anticonvulsant activities of ethanolic extract and aqueous fraction isolated from Delphinium denudatum Raza, M., et al., Journal of Ethnopharmacology, 2001. 78(1): p. 73-78.
5.    Anticonvulsant activities of the FS-1 subfraction isolated from roots of Delphinium denudatum Raza, M., et al., Phytotherapy Research, 2001. 15(5): p. 426-430.
6.    Anticonvulsant effect of FS-1 subfraction isolated from roots of Delphinim denudatum on hippocampal pyramidal neurons Raza, M., et al., Phytotherapy Research, 2003. 17(1): p. 38-43.
7.    Anticonvulsant effects in vivo and inhibition of neuronal excitability in vitro with aqueous fraction of delphinium denudatum Raza, M., et al., Society for Neuroscience Abstracts, 1997. 23(1-2): p. 2164-2164.
8.    Antifungal diterpenoid alkaloids from Delphinium denudatum AttaurRahman, et al., Journal of Natural Products, 1997. 60(5): p. 472-474.
9.    ANTIMICROBIAL AND IMMUNOMODULATING PROPERTIES OF DELPHINIUM-DENUDATUM EXTRACTS Siddiqui, R., S. Kazmi, and S. Shekhani, Abstracts of the Annual Meeting of the American Society for Microbiology, 1990. 90: p. 384-384.
10.    CNS depressant effect of delphinium denudatum wall. with special reference to its role in morphine addiction Rahman, S.Z., R.A. Khan, and A. Kumar, Journal of Neurochemistry, 2003. 87: p. 68-68.
11.    Delphinium denudatum Visvarup, C., MFP News, 2002. 12(3): p. 22-23.
12.    Delphinium denudatum Wall and its CNS activities particularly in morphine addiction Rahman, S.Z., R.A. Khan, and A. Kumar, Journal of Neurochemistry, 2004. 88: p. 34-34.
13.    Delphinium denudatum Wall and its CNS depressant effect particularly in morphine addiction Rahman, S.Z., R.A. Khan, and A. Kumar, Journal of Neurochemistry, 2004. 90: p. 145-145.
14.    EFFECT OF DELPHINIUM-DENUDATUM ON EXPERIMENTAL LIVER DAMAGE IN RATS Khan, A.B., et al., Indian Journal of Pharmacology, 1980. 12(1): p. 61-61.
15.    EFFECT OF JADWAR DELPHINIUM-DENUDATUM WALL ON EXPERIMENTAL LIVER DAMAGE IN RATS Khan, A.B. and H.M. Taiyab, Indian Journal of Pharmaceutical Sciences, 1981. 43(3): p. 120-122.
16.    Effect of roots aqueous extract of Delphinium denudatum on morphine-induced tolerance in mice Zafar, S., M.A. Ahmad, and T.A. Siddiqui, Fitoterapia, 2002. 73(7-8): p. 553-556.
17.    EFFECT OF THE AQUEOUS EXTRACT OF DELPHINIUM-DENUDATUM WALL AGAINST RADIATION INDUCED CHANGES IN RAT'S MYOCARDIUM Khan, A.B., Journal of Molecular and Cellular Cardiology, 1989. 21(SUPPL. 2): p. S171-S171.
18.    Experimental study of the morphine de-addiction properties of Delphinium denudatum Wall Rahman, S., R. Ali Khan, and A. Kumar, BMC complementary and alternative medicine, 2002. 2: p. 6-6.
19.    Green synthesis of silver nanoparticles using Delphinium denudatum root extract exhibits antibacterial and mosquito larvicidal activities Suresh, G., et al., Spectrochimica Acta Part a-Molecular and Biomolecular Spectroscopy, 2014. 127: p. 61-66.
20.    In vitro inhibition of pentylenetetrazole and bicuculline-induced epileptiform activity in rat hippocampal pyramidal neurons by aqueous fraction isolated from Delphinium denudatum Raza, M., et al., Neuroscience Letters, 2002. 333(2): p. 103-106.
21.    Inhibition of pentylenetetrazole- and bicuculline-induced epileptiform activity in cultured hippocampal neurons by an aqueous fraction isolated from delphinium denudatum Raza, M., et al., Epilepsia, 1997. 38(SUPPL. 8): p. 10-10.
22.    Inhibition of sustained repetitive firing (SRF) in cultures hippocampal neurons by an aqueous fraction isolated from Delphinium denudatum WALL.ex Hook.F. & Thoms Haidary, R., et al., Journal of Medicinal Plants, 2004. 3(9): p. 55-67.
23.    Inhibition of sustained repetitive firing in cultured hippocampal neurons by an aqueous fraction isolated from Delphinium denudatum Raza, M., et al., Journal of Ethnopharmacology, 2004. 90(2-3): p. 367-374.
24.    ISOLATION AND INVESTIGATIONS ON ALKALOID FROM ROOT OF DELPHINIUM-DENUDATUM WALL Tandon, S.P. and K.P. Tiwari, Proceedings of the National Academy of Sciences India Section a-Physical Sciences, 1969. 39: p. 233-&.
25.    Mechanism based protective effect of Delphinium denudatum on cisplatin induced nephrotoxicity Siddique, N.A., S. Ahmad, and M. Mujeeb, World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS), 2014. 3(3): p. 2063-2077.
26.    OCCURRENCE OF SMUT ON DELPHINIUM-DENUDATUM WALL. EX HOOK F. AND TH. IN CENTRAL HIMALAYA INDIA Melkania, N.P., Indian Journal of Plant Pathology, 1988. 6(1): p. 84-85.
27.    Pharmaceutical compositions based on phospholipid complexed microparticles of Delphinium denudatum (Jadwar) extract, a.t.p.m.K., R. K., et al. Cent Council Res in Unani Medicine.
28.    Pharmacognostical standardization of Delphinium denudatum Wall. (Jadwar). A cardiotonic drug Shamima, H. and A. Faizan, Hamdard Medicus, 1997. 40(2): p. 37-40.
29.    Pharmacological studies of an indigenous CNS-active drug delphinium denudatum wall. In view of its role in morphine addiction Rahman, S.Z., R.A. Khan, and A. Kumar, Journal of Neurochemistry, 2005. 94: p. 95-95.
30.    Pharmacological study of delphinium denudatum wall. In morphine de-addiction Rahman, S.Z., R.A. Khan, and A. Kumar, Journal of Neurochemistry, 2007. 102: p. 142-143.
31.    Protective effects of ethanolic extract of Delphinium denudatum in a rat model of Parkinson's disease Ahmad, M., et al., Human & Experimental Toxicology, 2006. 25(7): p. 361-368.
32.    Protective role of Delphinium denudatum (Jadwar) against morphine induced tolerance and dependence in mice Zafar, S., M.A. Ahmad, and T.A. Siddiqui, Journal of Ethnopharmacology, 2001. 78(1): p. 95-98.
33.    Role of Delphinium denudatum Wall. in heroin addicted patient: Case reports Rahman, S.Z., R.A. Khan, and A. Kumar, Indian Journal of Pharmacology, 2004. 36(3): p. 199-199.
34.    STRUCTURE OF HETISINONE Aplin, R.T., et al., Canadian Journal of Chemistry, 1968. 46(15): p. 2635-&.
35.    STUDY ON CARDIOTONIC PROPERTIES OF DELPHINIUM-DENUDATUM Khan, A.B., et al., Journal of Molecular and Cellular Cardiology, 1978. 10: p. 46-46.
36.    THE STEROLS AND FATTY-ACIDS OF DELPHINIUM DENUDATUM ROOTS Asif, M., et al., Fette Seifen Anstrichmittel, 1981. 83(8): p. 323-324.
37.    The structure of condelphine, i.a.t.D.d.P., S. W., L.H. Keith, and P.C. Parthasarathy, Tetrahedron Lett, 1966. 35: p. 4217-4222.
38.    Treatment of herpes and hepatitis virus infections and bronchitis|comprises medicament derived from wormwood, m.r.a.o.D.d.O., O. and O.L.M. Omer. Omer O; Omer O L M.
39.    Unani drug, J.D.d.W.-a.r.Q., Nizami and M.A. Jafri, Indian Journal of Traditional Knowledge, 2006. 5(4): p. 463-467.