Cichorium pumilum Jacq.
Family: Compositae
Synonyms: Cichorium ambiguum Schult., Cichorium dichotomum Link, Cichorium divaricatum Schousb., Cichorium endivia subsp. divaricatum (Schousb.) P.D.Sell, Cichorium endivia subsp. divaricatum (Schousb.) Ball, Cichorium endivia subsp. pumilum (Jacq.) Cout., Cichorium glandulosum Boiss. & A.Huet, Cichorium intybus var. callosum (Pomel) Batt., Cichorium intybus subsp. divaricatum (Schousb.) Bonnier & Layens, Cichorium intybus subsp. pumilum (Jacq.) Ball, Cichorium minimum Port., Cichorium nanum Port. ex Nyman, Cichorium noeanum Boiss., Cichorium polystachyum Pomel, Cichorium pumilum var. polystachyum (Pomel) Batt., Cichorium pumilum f. pumilum, Cichorium pumilum var. pumilum.
- Chinese: 腺毛菊苣
- Finnish: Kääpiöendiivi
- French: Endive sauvage
Laeves used in Rheumatism, bacterial and fungal infections. Foliage decoction Bacterial infection and rheumatism. Cichorium pumilum is a well-known food and traditional remedy. The plant as a whole contains several guaianolide sesquiterpene lactones. Similar compounds in other plants such as feverfew are known to have anti-inflammatory activity. Cichorium pumilum is known in European herbal medicine as helpful in cleaning the body and supporting the liver. It also stimulates the eliminative processes vis-a-vis both the intestine and the kidneys. Arabic traditional healers regard Cichorium pumilum as part of a combined treatment of metabolic problems, as well as a medicine to cleanse the body and treat colds and flu. [Greco-Arab and Islamic Herbal Medicine Traditional System, Ethics, Safety, Efficacy, and Regulatory Issues]
25 Published articles of Cichorium glandulosum / Cichorium pumilum
1. Tong, J., et al., The protective effects of Cichorium glandulosum seed and cynarin against cyclophosphamide and its metabolite acrolein-induced hepatotoxicity in vivo and in vitro. Food & Function, 2017. 8(1): p. 209-219.
2. Chen, H.-J., et al., Screening of High-Affinity alpha-Glucosidase Inhibitors from Cichorium Glandulosum Boiss. et Hout Seed Based on Ultrafiltration Liquid Chromatography-Mass Spectrometry and Molecular Docking. Chinese Journal of Analytical Chemistry, 2017. 45(6): p. 889-897.
3. Tong, J., et al., Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology, 2015. 174: p. 355-363.
4. Tong, J., et al., Dicaffeoylquinic Acid-Enriched Fraction of Cichorium glandulosum Seeds Attenuates Experimental Type 1 Diabetes via Multipathway Protection. Journal of Agricultural and Food Chemistry, 2015. 63(50): p. 10791-10802.
5. Qin, D., Y. Nie, and Z. Wen, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Iranian Journal of Basic Medical Sciences, 2014. 17(11): p. 879-885.
6. Huang, B., et al., Protective effect of Cichorium glandulosum seeds from ultraviolet B-induced damage in rat liver mitochondria. Food & Function, 2014. 5(5): p. 869-875.
7. Ding, L., et al., Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes. Scientific Reports, 2014. 4.
8. Zhou, J., et al., HPLC fingerprint and chemical pattern recognition method for Cichorium intybus and C. glandulosum. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013. 38(9): p. 1401-5.
9. Yao, X., et al., In vivo and in vitro antioxidant activity and alpha-glucosidase, alpha-amylase inhibitory effects of flavonoids from Cichorium glandulosum seeds. Food Chemistry, 2013. 139(1-4): p. 59-66.
10. Qin, D.-m., et al., Effects of Cichorium glandulosum Boiss. et Huet. on expression of fibronectin, Smad3, IGFBP-rPl, and TGFbeta1 in a liver fibrosis rat model. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2013. 21(10): p. 776-7.
11. Qin, D., et al., Effect of Cichorium Glandulosum Extracts on CCl4-Induced Hepatic Fibrosis. Iranian Red Crescent Medical Journal, 2013. 15(12).
12. Yang, W.-J., et al., Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum. Chinese Medicine, 2012. 7.
13. Qin, D.-m., et al., Protective effects of Cichorium glandulosum Boiss extracts on experimental liver injury in mice. Zhongguo Yaolixue Tongbao, 2012. 28(8): p. 1180-1181.
14. Wu, H.K., et al., 2-ISOPROPYL-6-METHYLPYRIMIDIN-4(3H)-ONE AND TARAXASTEROL FROM THE STEMS OF Cichorium glandulosum. Chemistry of Natural Compounds, 2011. 47(4): p. 664-666.
15. Zaynap, T., et al., Comparative studies in content of major active compositions in different parts of Cichorium glandulosum. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010. 35(8): p. 1018-21.
16. Wu, H., et al., Two New Sesquiterpene Lactones and a Triterpene Glycoside from Cichorium glandulosum. Helvetica Chimica Acta, 2010. 93(3): p. 414-421.
17. Yang, W.-Z., et al., Chemical Constituents from Cichorium glandulosum. Chinese Journal of Natural Medicines, 2009. 7(3): p. 193-195.
18. Upur, H., et al., Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice. Food and Chemical Toxicology, 2009. 47(8): p. 2022-2030.
19. Pei, L.-p., et al., Determination of Eight Metal Elements in Cichorium glandulosum Boiss et Huet by Microwave Digestion-FAAS. Spectroscopy and Spectral Analysis, 2009. 29(12): p. 3412-3415.
20. Wu, H.K., et al., Polysaccharides from Cichorium glandulosum seeds. Chemistry of Natural Compounds, 2008. 44(1): p. 79-80.
21. Wu, H.K., et al., Isolation of esculetin from Cichorium glandulosum by high-speed countercurrent chromatography. Chemistry of Natural Compounds, 2007. 43(1): p. 109-109.
22. Wu, H.K., et al., Components of Cichorium glandulosum seeds. Chemistry of Natural Compounds, 2007. 43(4): p. 472-473.
23. Wu, H., et al., Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography. Journal of Chromatography A, 2007. 1176(1-2): p. 217-222.
24. Zhang, Y., X. Jin, and J. Chen, Preparation of kaempferol-3-O-beta-D-glucopyranoside involves extracting dried Cichorium glandulosum in ethanol, combining filtrates, concentrating, suspending in water, extracting in organic solvent, and separating in silica gel column. Jiangsu Hanbon Sci & Technology Co Ltd.
25. Chen, S., et al., Use of Cichorium glandulosum and Portulaca olerace L. extract in e.g. preparation of hepatoprotective drugs and health products. Univ Minzu China.
2. Chen, H.-J., et al., Screening of High-Affinity alpha-Glucosidase Inhibitors from Cichorium Glandulosum Boiss. et Hout Seed Based on Ultrafiltration Liquid Chromatography-Mass Spectrometry and Molecular Docking. Chinese Journal of Analytical Chemistry, 2017. 45(6): p. 889-897.
3. Tong, J., et al., Hepatoprotective activity of flavonoids from Cichorium glandulosum seeds in vitro and in vivo carbon tetrachloride-induced hepatotoxicity. Journal of Ethnopharmacology, 2015. 174: p. 355-363.
4. Tong, J., et al., Dicaffeoylquinic Acid-Enriched Fraction of Cichorium glandulosum Seeds Attenuates Experimental Type 1 Diabetes via Multipathway Protection. Journal of Agricultural and Food Chemistry, 2015. 63(50): p. 10791-10802.
5. Qin, D., Y. Nie, and Z. Wen, Protection of rats from thioacetamide-induced hepatic fibrosis by the extracts of a traditional Uighur medicine Cichorium glandulosum. Iranian Journal of Basic Medical Sciences, 2014. 17(11): p. 879-885.
6. Huang, B., et al., Protective effect of Cichorium glandulosum seeds from ultraviolet B-induced damage in rat liver mitochondria. Food & Function, 2014. 5(5): p. 869-875.
7. Ding, L., et al., Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes. Scientific Reports, 2014. 4.
8. Zhou, J., et al., HPLC fingerprint and chemical pattern recognition method for Cichorium intybus and C. glandulosum. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013. 38(9): p. 1401-5.
9. Yao, X., et al., In vivo and in vitro antioxidant activity and alpha-glucosidase, alpha-amylase inhibitory effects of flavonoids from Cichorium glandulosum seeds. Food Chemistry, 2013. 139(1-4): p. 59-66.
10. Qin, D.-m., et al., Effects of Cichorium glandulosum Boiss. et Huet. on expression of fibronectin, Smad3, IGFBP-rPl, and TGFbeta1 in a liver fibrosis rat model. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2013. 21(10): p. 776-7.
11. Qin, D., et al., Effect of Cichorium Glandulosum Extracts on CCl4-Induced Hepatic Fibrosis. Iranian Red Crescent Medical Journal, 2013. 15(12).
12. Yang, W.-J., et al., Hepatoprotective activities of a sesquiterpene-rich fraction from the aerial part of Cichorium glandulosum. Chinese Medicine, 2012. 7.
13. Qin, D.-m., et al., Protective effects of Cichorium glandulosum Boiss extracts on experimental liver injury in mice. Zhongguo Yaolixue Tongbao, 2012. 28(8): p. 1180-1181.
14. Wu, H.K., et al., 2-ISOPROPYL-6-METHYLPYRIMIDIN-4(3H)-ONE AND TARAXASTEROL FROM THE STEMS OF Cichorium glandulosum. Chemistry of Natural Compounds, 2011. 47(4): p. 664-666.
15. Zaynap, T., et al., Comparative studies in content of major active compositions in different parts of Cichorium glandulosum. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010. 35(8): p. 1018-21.
16. Wu, H., et al., Two New Sesquiterpene Lactones and a Triterpene Glycoside from Cichorium glandulosum. Helvetica Chimica Acta, 2010. 93(3): p. 414-421.
17. Yang, W.-Z., et al., Chemical Constituents from Cichorium glandulosum. Chinese Journal of Natural Medicines, 2009. 7(3): p. 193-195.
18. Upur, H., et al., Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice. Food and Chemical Toxicology, 2009. 47(8): p. 2022-2030.
19. Pei, L.-p., et al., Determination of Eight Metal Elements in Cichorium glandulosum Boiss et Huet by Microwave Digestion-FAAS. Spectroscopy and Spectral Analysis, 2009. 29(12): p. 3412-3415.
20. Wu, H.K., et al., Polysaccharides from Cichorium glandulosum seeds. Chemistry of Natural Compounds, 2008. 44(1): p. 79-80.
21. Wu, H.K., et al., Isolation of esculetin from Cichorium glandulosum by high-speed countercurrent chromatography. Chemistry of Natural Compounds, 2007. 43(1): p. 109-109.
22. Wu, H.K., et al., Components of Cichorium glandulosum seeds. Chemistry of Natural Compounds, 2007. 43(4): p. 472-473.
23. Wu, H., et al., Isolation of three sesquiterpene lactones from the roots of Cichorium glandulosum Boiss. et Huet. by high-speed counter-current chromatography. Journal of Chromatography A, 2007. 1176(1-2): p. 217-222.
24. Zhang, Y., X. Jin, and J. Chen, Preparation of kaempferol-3-O-beta-D-glucopyranoside involves extracting dried Cichorium glandulosum in ethanol, combining filtrates, concentrating, suspending in water, extracting in organic solvent, and separating in silica gel column. Jiangsu Hanbon Sci & Technology Co Ltd.
25. Chen, S., et al., Use of Cichorium glandulosum and Portulaca olerace L. extract in e.g. preparation of hepatoprotective drugs and health products. Univ Minzu China.
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