Monday, January 20, 2014

Biophytum sensitivum, Pulichinta, Mukkutti

Biophytum sensitivum (L.) DC.
Family: Oxalidaceae

Synonyms: Biophytum somnulentum Goebel , Biophytum sesbanioides Edgew. & Hook.f. , Biophytum poterioides Edgew. & Hook.f. , Biophytum nervifolium Thwaites , Biophytum homblei De Wild. , Biophytum cumingii Klotzsch , Biophytum cumingianum (Turcz.) Edgew. & Hook.f. , Biophytum candolleanum Wight , Biophytum bogoroense De Wild. , Biophytum bequaertii De Wild.

Chinese: 感应草
Bengali: ঝলৈ jhalai
Hindi: alm bhusha, लज्जालू lajjaalu, lakshmana
Kannada: hara muni, jalapushpa
Malayalam: മുക്കുറ്റി mukkutti
Marathi: झरेरा jharera, लाजवंती lajwanti
Sanskrit: झुल्लिपुष्प jhullipuspa, लजालू lajalu, पङ्क्तिपत्र panktipatra, pitapushpa, vipareetalajjaalu, alambusha, jalapushpa, peethapushpa, samanga, krithanjali
Tamil: nilaccurunki, tintaanaalee
Telugu: attapatti, chumi, jala puspa, పులిచింత pulicenta
Uses:  Astringent, antipyretic, anti-septic [MEDICINAL PLANTS]
Activities: Analgesic ,  Antiangiogenic ,  Antiaphrodisiac ,  Anticancer ,  Antiedemic ,  Antiinflammatory ,  Antioxidant ,  Antiseptic ,  Antisialogogue ,  Antitumor , Astringent, Bitter, Contraceptive, COXI-Inhibitor, Diuretic, Expectorant, Febrifuge, Hypoglycemic, Insulinotropic,  Litholytic, Sterilant, Stimulant, Tonic,  Vulnerary .
Indications: Abscesses , Asthma, Biliousness, Bruises,  Burns, Cancer, Collapse,  Convulsions,  Cramps,  Dermatosis ,  Diabetes ,  Edema ,  Fever , Gastrosis, Gonorrhea, Hyperglycemia,  Infection ,  Inflammation,  Insomnia , Mycobacterium; Pain, Phthisis, Pulmonosis, Spasms, Stomachache, Stones, Strangury, Swelling, Thirst, Tuberculosis, Tumors, VD, Wounds. [Duke’s Handbook of MEDICINAL PLANTS OF LATIN AMERICA]

Rural folk of Orissa and ethnic communities of Sagar district consider the plant as antiexcitant. Bhils use root to decrease sexual vigour; and the ethnic communities of Ratan Mahal Hills (Gujarat) maintain that smoking dried leaves with tobacco reduces the reproductive capabilities of man, and excessive use of the same renders him impotent. Kasis, Jaintias and Santals find different parts of the plant beneficial for diverse diseases. [HERBAL CURES: TRADITIONAL APPROACH]

Plant—used in insomnia, convulsions, cramps, chest-complaints, inflammations, tumours, chronic skin diseases. Ash—in stomachache. Leaves— diuretic, astringent, antiseptic. Paste is applied to burns, contusions and wounds. Decoction is given in strangury, asthma and phthisis. Roots—decoction is given in lithiasis. Mature leaves are recommended in diabetes; contain an insulin-like principle. A saline extract of leaves showed hypoglycaemic activity in rabbits. [Indian Medicinal Plants An Illustrated Dictionary]

36 Published articles of Biophytum sensitivum
1.    Fibro-porous polycaprolactone membrane containing extracts of Biophytum sensitivum: A prospective antibacterial wound dressing
Namboodiri, Arjun Govindan; Parameswaran, Ramesh
JOURNAL OF APPLIED POLYMER SCIENCE  Volume: 129   Issue: 4   Pages: 2280-2286   Published: AUG 15 2013
2.    Bioefficacy of leaf extracts of Biophytum sensitivum (L.) DC. against Aedes aegypti (Diptera : Culicidae)
Shivakumar, M. S.; Natarajan, D.; Srinivasan, R.
RESEARCH JOURNAL OF BIOTECHNOLOGY  Volume: 8   Issue: 3   Pages: 67-70   Published: MAR 2013
3.    Biophytum sensitivum: Ancient medicine, modern targets.
Sakthivel, K M; Guruvayoorappan, C
Journal of advanced pharmaceutical technology & research  Volume: 3   Issue: 2   Pages: 83-91   Published: 2012-Apr
4.    Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats.
Ananda, Prabu K; Kumarappan, Ct; Sunil, Christudas; et al.
Asian Pacific journal of tropical biomedicine  Volume: 2   Issue: 1   Pages: 31-5   Published: 2012-Jan
5.    Ethnobotany, phytochemistry and pharmacology of Biophytum sensitivum DC.
Bharati, Abinash C; Sahu, Alakh N
Pharmacognosy reviews  Volume: 6   Issue: 11   Pages: 68-73   Published: 2012-Jan
6.    Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats
Prabu, Ananda K.; Kumarappan, C. T.; Christudas, Sunil; et al.
Asian Pacific Journal of Tropical Biomedicine  Volume: 2   Issue: 1   Pages: 31-35   Published: JAN 2012
7.    Effect of Amentoflavone, a Phenolic Component From Biophytum sensitivum, on Cell Cycling and Apoptosis of B16F-10 Melanoma Cells
Siveen, K. S.; Kuttan, Girija
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY  Volume: 30   Issue: 4   Pages: 301-309   Published: 2011
8.    Regeneration of Biophytum sensitivum (Linn.) DC. through organogenesis and somatic embryogenesis
Shivanna, M. B.; Vasanthakumari, M. M.; Mangala, M. C.
INDIAN JOURNAL OF BIOTECHNOLOGY  Volume: 8   Issue: 1   Pages: 127-131   Published: JAN 2009
9.    Biophytum seusitivum (L.) DC inhibits tumor cell invasion and metastasis through a mechanism involving regulation of MMPs, prolyl hydroxylase, lysyl oxidase, nm23, ERK-1, ERK-2, STAT-1, and proinflammatory cytokine gene expression in metastatic lung tissue
Guruvayoorappan, Chandrasekharan; Kuttan, Girija
INTEGRATIVE CANCER THERAPIES  Volume: 7   Issue: 1   Pages: 42-50   Published: MAR 2008
10.    Methanol extract of Biophytum sensitivum alters the cytokine profile and inhibits iNOS and COX-2 expression in LPS/Con a stimulated macrophages
Guruvayoorappan, Chandrasekharan; Kuttan, Girija
DRUG AND CHEMICAL TOXICOLOGY  Volume: 31   Issue: 1   Pages: 175-188   Published: 2008
11.    Protective Effect of Biophytum sensitivum (L.) DC on Radiation-Induced Damage in Mice
Guruvayoorappan, C.; Kuttan, Girija
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY  Volume: 30   Issue: 4   Pages: 815-835   Published: 2008
12.    Anti-metastatic effect of Biophytum sensitivum is exerted through its cytokine and immunomodulatory activity and its regulatory effect on the activation and nuclear translocation of transcription factors in B16F-10 melanoma cells.
Guruvayoorappan, Chandrasekharan; Kuttan, Girija
Journal of experimental therapeutics & oncology  Volume: 7   Issue: 1   Pages: 49-63   Published: 2008
13.    Apoptotic effect of Biophytum sensitivum on B16F-10 cells and its regulatory effects on nitric oxide and cytokine production on tumor-associated macrophages
Guruvayoorappan, C.; Kuttan, Girija
INTEGRATIVE CANCER THERAPIES  Volume: 6   Issue: 4   Pages: 373-380   Published: DEC 2007
14.    Immunomodulatory and antitumor activity of Biophytum sensitivum extract
Guruvayoorappan, C.; Kuttan, Girija
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION  Volume: 8   Issue: 1   Pages: 27-32   Published: JAN-MAR 2007
15.    Evaluation of the chemoprotective effect of Biophytum sensitivum (L.) DC extract against cyclophosphamide induced toxicity in swiss albino mice
Guruvayoorappan, C.; Kuttan, Girija
Drug Metabolism and Drug Interactions  Volume: 22   Issue: 2-3   Pages: 131-150   Published: 2007
16.    Effect of Biophytum sensitivum on cell-mediated immune response in mice
Guruvayoorappan, C.; Kuttan, G.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY  Volume: 29   Issue: 3-4   Pages: 337-350   Published: 2007
17.    Anti-angiogenic effect of Biophytum sensitivum is exerted through its cytokine modulation activity and inhibitory activity against VEGF mRNA expression, endothelial cell migration and capillary tube formation.
Guruvayoorappan, Chandrasekharan; Kuttan, Girija
Journal of experimental therapeutics & oncology  Volume: 6   Issue: 3   Pages: 241-50   Published: 2007
18.    Amentoflavone, a biflavonoid from Biophytum sensitivum augments lymphocyte proliferation, natural killer cell and antibody dependent cellular cytotoxicity through enhanced production of IL-2 and IFN-gamma and restrains serum sialic acid and gamma glutamyl transpeptidase production in tumor - bearing animals.
Guruvayoorappan, Chandrasekharan; Kuttan, Girija
Journal of experimental therapeutics & oncology  Volume: 6   Issue: 4   Pages: 285-95   Published: 2007
19.    Effect of leaf extract of biophytum Sensitivum (LNN.), on fish Labeo rohita
Varsha, Rathod; Chaudhari, U. S.
BRI'S Journal of Advances in Science and Technology  Volume: 9   Issue: 1-2   Pages: 77-81   Published: JUN-DEC 2006
20.    Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo
Guruvayoorappan, C.; Afira, A. H.; Kuttan, Girija
Journal of Basic and Clinical Physiology and Pharmacology  Volume: 17   Issue: 4   Pages: 255-267   Published: 2006
21.    Effect of biophytum sensitivum on B16F-10 melanoma cells induced metastasis
[Anonymous]
INDIAN JOURNAL OF MEDICAL RESEARCH  Volume: 121   Supplement: S   Pages: 128-129   Published: FEB 2005
22.    Effect of biophytum sensitivum on B16F-10 melanoma cells induced metastasis
Guruvayoorappan, C.; Kuttan, Girija
Conference: 24th Annual Convention of the Indian-Association-for-Cancer-Research/International Symposium on Human Papillomavirus and Cervical Cancer Location: Noida, INDIA Date: February 09 -12, 2005
Sponsor(s): Indian Assoc Canc Res
Indian Journal of Medical Research  Volume: 121   Issue: Suppl. S   Pages: 128-129   Published: FEB 2005
23.    Hypocholesterolemic effect of Biophytum sensitivum leaf water extract
Puri, D
PHARMACEUTICAL BIOLOGY  Volume: 41   Issue: 4   Pages: 253-258   Published: JUN 2003
24.    A sensitive HPTLC method for estimation of amentoflavone, a bioactive principle from Biophytum sensitivum (Linn.) DC. and Putranjiva roxburghii wall.
Ravishankara, MN; Pillai, AD; Padh, H; et al.
JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC  Volume: 16   Issue: 3   Pages: 201-205   Published: MAY-JUN 2003
25.    Pollen features and germination of Biophytum sensitivum var. sensitivum DC.
Sreedevi, P.; Rekha, B.
Phytomorphology  Volume: 53   Issue: 2   Pages: 157-164   Published: April-June 2003
26.    Chemical constituents of Biophytum sensitivum.
Lin, Yun-Lian; Wang, Wan-Yi
Chinese Pharmaceutical Journal (Taipei)  Volume: 55   Issue: 1   Pages: 71-75   Published: February 2003
27.    The insulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study
Puri, D
JOURNAL OF ETHNOPHARMACOLOGY  Volume: 78   Issue: 1   Pages: 89-93   Published: NOV 2001
28.    Antiinflammatory activity of extracts of Biophytum sensitivum in carrageenin-induced rat paw oedema
Jachak, SM; Bucar, F; Kartnig, T
PHYTOTHERAPY RESEARCH  Volume: 13   Issue: 1   Pages: 73-74   Published: FEB 1999
29.    Phenolic compounds from Biophytum sensitivum
Bucar, F; Jachak, SM; Karting, T; et al.
PHARMAZIE  Volume: 53   Issue: 9   Pages: 651-653   Published: SEP 1998
30.    Hypoglycemic effect of biophytum sensitivum in the alloxan diabetic rabbits
Puri, Dinesh; Baral, Nirmal
Indian Journal of Physiology and Pharmacology  Volume: 42   Issue: 3   Pages: 401-406   Published: July, 1998
31.    Amentoflavone from Biophytum sensitivum and its effect on COX-1/COX-2 catalysed prostaglandin biosynthesis
Bucar, F; Jackak, SM; Noreen, Y; et al.
PLANTA MEDICA  Volume: 64   Issue: 4   Pages: 373-374   Published: MAY 1998
32.    Application of leaf extract causes repetitive action potentials in Biophytum sensitivum
Sibaoka, T
JOURNAL OF PLANT RESEARCH  Volume: 110   Issue: 1100   Pages: 485-487   Published: DEC 1997
33.    THE EFFECTS OF TEMPERATURE ON ACTION-POTENTIALS IN THE CHILL SENSITIVE SEISMONASTIC PLANT BIOPHYTUM-SENSITIVUM
JONES, C; WILSON, JM
JOURNAL OF EXPERIMENTAL BOTANY  Volume: 33   Issue: 133   Pages: 313-320   Published: 1982
34.    A NEW BACTERIAL DISEASE OF BIOPHYTUM SENSITIVUM
PATEL, AM; CHAUHAN, JM; KOTASTHA.WV; et al.
CURRENT SCIENCE  Volume: 38   Issue: 11   Pages: 274-&   Published: 1969
35.    HOMOSTYLY IN HETEROSTYLED BIOPHYTUM SENSITIVUM DC
DEVI, PM; HASHIM, M
JOURNAL OF GENETICS  Volume: 59   Issue: 3   Pages: 245-&   Published: 1966
36.    HETEROSTYLY IN BIOPHYTUM SENSITIVUM DC
DEVI, PM
JOURNAL OF GENETICS  Volume: 59   Issue: 1   Pages: 41-&   Published: 1964

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indica Pentapetes phoenicea Pentas lanceolata Peperomia argyreia Peperomia heyneana Peperomia pellucida Peperomia sandersii Peperomia tetraphylla Perilla frutescens Persicaria amplexicaulis Persicaria barbata Persicaria capitata Persicaria glabra Persicaria nepalensis Phalaenopsis taenialis Phaulopsis dorsiflora Philodendron bipinnatifidum Phlomis bracteosa Phlomoides bracteosa Phyllanthus acidus Phyllanthus amarus Phyllanthus fraternus Phyllanthus lawii Phyllanthus rotundifolius Physalis grisea Physalis peruviana Picrorhiza kurroa Pilea microphylla Pimpinella anisum Piper betle Piper longum Piper nigrum Pisonia aculeata Pistia stratiotes Pisum sativum Plantago orbignyana Plantago ovata Platanthera edgeworthii Platostoma elongatum Plectranthus barbatus Plectranthus scutellarioides Plumbago auriculata Plumbago capensis Plumbago zeylanica Plumeria rubra Podranea ricasoliana Polemonium caeruleum Polygala crotalarioides Polygala persicariifolia Polygonatum cirrhifolium Polygonatum verticillatum Polygonum amplexicaule Polygonum barbatum Polygonum recumbens Pongamia pinnata Portulaca oleracea Portulaca umbraticola Portulacaria afra Potentilla fruticosa Potentilla supina Premna corymbosa Premna tomentosa Primula denticulata Primula floribunda Primula vulgaris Prunus Amygdalus Prunus dulcis Pseuderanthemum carruthersii Pseudobombax ellipticum Pseudocaryopteris foetida Psidium guajava Psidium guineense Pterocarpus santalinus Pterospermum acerifolium Pterospermum lanceifolium Pterygota alata Pulicaria dysenterica Punica granatum Putranjiva roxburghii Pyrostegia venusta Quisqualis indica Ranunculus arvensis Ranunculus laetus Ranunculus sceleratus Raphanus sativus Rauvolfia serpentina Rauvolfia tetraphylla Reinwardtia indica Rhamphicarpa fistulosa Rhodiola trifida Rhodiola wallichiana Rhododendron arboreum Rhynchosia heynei Rhynchosia himalensis Rhynchosia viscosa Ricinus communis Rorippa indica Roscoea purpurea Rosmarinus officinalis Ruellia patula Ruellia prostrata Ruellia tuberosa Rumex dentatus Rumex hastatus Rungia pectinata Saccharum officinarum Saccharum spontaneum Salix denticulata Salix tetrasperma Salvadora persica Salvia involucrata Salvia miltiorrhiza Salvia nubicola Salvia splendens Sambucus canadensis Sambucus mexicana Sambucus nigra Santalum album Sapindus saponaria Saussurea auriculata Saussurea candicans Saussurea obvallata Scadoxus multiflorus Scutellaria baicalensis Scutellaria grossa Scutellaria repens Sedum oreades Semecarpus anacardium Senna auriculata Senna occidentalis Senna siamea Senna sophera Sesbania bispinosa Sesbania grandiflora Seseli diffusum Sesuvium portulacastrum Setaria verticillata Shorea robusta Sida cordata Sida cordifolia Sida retusa Sida spinosa Sideritis hirsuta Silybum marianum Smithia ciliata Solanum chrysotrichum Solanum erianthum Solanum jasminoides Solanum melongena Solanum nigrum Solanum sisymbriifolium Solanum surattense Solanum torvum Solanum tuberosum Solanum villosum Sonchus oleraceus Soymida febrifuga Sphaeranthus amaranthoides Sphenoclea zeylanica Spiranthes australis Spiranthes sinensis Spondias pinnata Stellaria media Stellera chamaejasme Stephania japonica Sterculia alata Sterculia foetida Sterculia villosa Stereospermum tetragonum Stevia rebaudiana Striga asiatica Strophanthus boivinii Strychnos minor Strychnos nux-vomica Strychnos potatorum Suaeda maritima Suregada multiflora Swertia angustifolia Swertia bimaculata Swertia cordata Swertia paniculata Swietenia macrophylla Swietenia mahagoni Syzygium alternifolium Syzygium aromaticum Syzygium cumini Syzygium jambos Syzygium samarangense Tabebuia aurea Tabebuia avellanedae Talinum portulacifolium Tamarindus indica Taxus baccata Tecoma castanifolia Tephrosia calophylla Tephrosia purpurea Teramnus labialis Terminalia alata Terminalia catappa Terminalia chebula Terminalia elliptica Terminalia pallida Teucrium botrys Teucrium royleanum Thalictrum foliolosum Thespesia populnea Thunbergia erecta Thunbergia fragrans Thunbergia grandiflora Thymus linearis Tiliacora acuminata Tiliacora racemosa Tinospora cordifolia Tinospora crispa Tinospora sinensis Toona ciliata Trewia nudiflora Tribulus terrestris Trichodesma indicum Trichosanthes cucumerina Trichosanthes palmata Trichosanthes tricuspidata Trifolium repens Trigonella foenum-graecum Triumfetta rhomboidea Tylophora indica Uraria picta Urena lobata Urena sinuata Urginea coromandeliana Vachellia horrida Valeriana jatamansi Vanda tessellata Veronica serpyllifolia Viburnum coriaceum Vicia bakeri Vicia faba Vicia sativa Vigna radiata Vigna unguiculata Vinca rosea Viola rupestris Viscum album Vitex negundo Vitis vinifera Withania somnifera Wrightia tinctoria Wulfeniosis amherstiana Zamia furfuracea Ziziphus jujuba Ziziphus mauritiana
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