Eupatorium perfoliatum L.Family: Compositae / Asteraceae
Synonyms: Cunigunda perfoliata, Eupatorium chapmanii, Eupatorium connatum, Eupatorium salviifolium, Eupatorium truncatum, Uncasia perfoliata, Uncasia truncata
Common names: Agueweed, Boneset, Bonset, Common Boneset, Common Thoroughwort, Feverwort, Indian Sage, Thoroughwax, Thoroughwort
Deutsch: Durchwachsener Wasserdost
French: Eupatoire Perfoliée
Uses: Boneset is native to North America and has a long history of use among Native Americans, Eclectic physicians, and physiomedicalists. It is a strong bitter that acts on the liver and gallbladder, and it has a strong diaphoretic action that gives it great utility in reducing fevers due to influenza.
Used in sweat baths as an emetic to eliminate cold and bile.[Florida ethnobotany]
Indications (Boneset) — Anorexia, Arthrosis, Backache, Bacteria, Biliousness, Bleeding, Bronchosis, Bruise, Cancer, Catarrh, Chill, Cold, Constipation, Cough, Cramp, Debility, Dengue, Dermatosis, Dropsy, Dysmenorrhea, Dyspepsia, Fever, Flu, Fracture, Gastrosis, Gonorrhea, Gout, Headache, Hematemesis, Hemorrhoid, Immunodepression, Indigestion, Infection, Inflammation, Insomnia, Malaria, Myalgia, Nephrosis, Osteosis, Pain, Pharyngosis, Pleurisy, Pneumonia, Rheumatism, Snakebite, Sore Throat, Stomachache, Tumor, Typhoid, Ulcer, Urethrosis, Virus, Water Retention. [Handbook of Medicinal Herbs]
Eupatorium perfoliatum is both a rich source of quercetin and a traditional treatment for flu. Quercetin may also play a role in tumor inhibition. [Medical Herbalism The Science And Practice Of Herbal Medicine]
Boneset (Eupatorium perfoliatum L.) also known as ague weed, thorough stem or thoroughwort, cross wort, and Indian sage. According to Reuter, boneset was "so called because the Indians use it as splints in binding a broken arm or leg," or the name may have resulted from the plant's use against breakbone fever or dengue. [Southern Folk Medicine 1750–1820 by Kay K. Moss]
Times of India News - Plant for Dengue Dt. 13 Nov 2012
The King Institute team headed by a Chennai-based homoeopath administered the drug extracted from Eupatorium perfoliatum to 50 patients with secondary dengue and found all of them recovered. “The platelet counts came under control for almost all patients and blood tests showed marked improvement,” said King Institute director Dr P Gunasekaran. The study, lead by Dr N R Jayakumar of Madan Homoeo Clinic, was presented at an international symposium on ‘Challenges and strategies in the prevention and management of viral infections’ at Central Learther Research Institute recently.
Jayakumar said it wasn’t a new idea to administer the drug to patients with dengue. Earlier the drug was given to patients in Delhi and Sri Lanka during epidemics. In June, the drug was administered to dengue patients at the Madurai Government Rajaji Hospitals. “We wanted to scientifically prove the drug is efficient. The patients were given two doses a day. The platelet count of all the patients improved. The good thing about this drug is that it can also be given alongside allopathic medicines,” Dr Jayakumar said.
“In allopathic medicine, there is no drug for this disease. The only treatment is IV fluids to replace body fluids. Most patients we chose for the study had platelet count less than 10,000. We prevented death and blood transfusion in all the 50 patients who took this drug,” said Dr Gunasekaran.
Dengue virus is spread by aedes mosquito. The symptoms include fever, headache, body pain and rashes. Some patients develop life-threatening dengue hemorrhagic fever, resulting in bleeding, low levels of blood platelets and blood plasma leakage.
Published articles & Patents of Eupatorium perfoliatum
1. Bioassay-guided fractionation of Eupatorium Perfoliatum L. towards anti-Influenza A-activity leads to dicaffeoyl quinic acids
Derksen, A.; Sendker, J.; Hafezi, W.; et al.
Conference: International Congress on Natural Products Research on Global Change, Natural Products and Human Health/8th Joint Meeting of AFERP, ASP, GA, PSE and SIF Location: New York, NY Date: JUL 28-AUG 01, 2012 - PLANTA MEDICA Volume: 78 Issue: 11 Pages: 1087-1087 Published: AUG 2012
2. Eupatorium perfoliatum L.: Phytochemistry, traditional use and current applications
Hensel, Andreas; Maas, Mareike; Sendker, Jandirk; et al. - JOURNAL OF ETHNOPHARMACOLOGY Volume: 138 Issue: 3 Pages: 641-651 DOI: http://dx.doi.org/10.1016/j.
3. Anti-inflammatory activity of Eupatorium perfoliatum L. extracts, eupafolin, and dimeric guaianolide via iNOS inhibitory activity and modulation of inflammation-related cytokines and chemokines
Maas, Mareike; Deters, Alexandra M.; Hensel, Andreas - JOURNAL OF ETHNOPHARMACOLOGY Volume: 137 Issue: 1 Pages: 371-381 DOI: http://dx.doi.org/10.1016/j.
4. An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatorium perfoliatum
Maas, Mareike; Hensel, Andreas; da Costa, Fernando Batista; et al. - PHYTOCHEMISTRY Volume: 72 Issue: 7 Pages: 635-644 DOI: http://dx.doi.org/10.1016/j.
5. Eupatorium perfoliatum L.: Antiinflammatory and antiplasmodial activity of the dichloromethane extract and novel sesquiterpene lactones
Maas, M.; da Costa, F.; Deters, A.; et al.
Conference: 7th Tannin Conference/58th International Congress and Annual Meeting of the Society-for-Medical-Plant-and-
6. Homeopathic pharmaceutical composition used for treating dengue fever and preventing e.g. hemorrhagic complications, comprises Crotalus horridus, Eupatorium perfoliatum and phosphorus
Patent Number: WO2010071951-A1; BR200805555-A2
Patent Assignee: FARMACIA E LAB HOMEOPATICO ALMEIDA PRADO LTDA
7. Capillary electrophoresis of phenolic compounds from Eupatorium perfoliatum L. (Asteraceae)
Lechtenberg, M.; Maas, M.; Quandt, B.; et al.
Conference: 55th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-
8. Caffeic Acid Derivatives from Eupatorium perfoliatum L.
Maas, Mareike; Petereit, Frank; Hensel, Andreas - MOLECULES Volume: 14 Issue: 1 Pages: 36-45 DOI: http://dx.doi.org/10.3390/
9. Activity-guided isolation and identification of free radical-scavenging components from ethanolic extract of Boneset (leaves of Eupatorium perfoliatum)
Habtemariam, Solomon - NATURAL PRODUCT COMMUNICATIONS Volume: 3 Issue: 8 Pages: 1317-1320 Published: 2008
10. Effects of homeopathic medications Eupatorium perfoliatum and Arsenicum album on parasitemia of Plasmodium berghei-infected mice
Lira-Salazar, G.; Marines-Montiel, E.; Torres-Monzon, J.; et al. - HOMEOPATHY Volume: 95 Issue: 4 Pages: 223-228 DOI: http://dx.doi.org/10.1016/j.
11. Cytotoxicity and antibacterial activity of ethanol extract from leaves of a herbal drug, boneset (Eupatorium perfoliatum)
Habtemariam, S; Macpherson, AM - PHYTOTHERAPY RESEARCH Volume: 14 Issue: 7 Pages: 575-577 DOI: http://dx.doi.org/10.1002/
12. Herbal composition for treating mastitis in cows and sheep|containing extracts of Aconitum napellus, Atropa belladonna, Eupatorium perfoliatum and Phytolacca decandra
Patent Number: ZA9808643-A
Patent Assignee: LOMBARD J J
13. IMMUNOLOGICALLY ACTIVE POLYSACCHARIDES OF EUPATORIUM-CANNABINUM AND EUPATORIUM-PERFOLIATUM
VOLLMAR, A; SCHAFER, W; WAGNER, H - PHYTOCHEMISTRY Volume: 25 Issue: 2 Pages: 377-381 DOI: http://dx.doi.org/10.1016/
14. A CONTROLLED CLINICAL-TRIAL FOR TESTING THE EFFICACY OF THE HOMEOPATHIC DRUG EUPATORIUM PERFOLIATUM D2 IN THE TREATMENT OF COMMON COLD
GASSINGER, CA; WUNSTEL, G; NETTER, P - ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH Volume: 31-1 Issue: 4 Pages: 732-736 Published: 1981
15. SESQUITERPENE LACTONES OF EUPATORIUM-PERFOLIATUM
HERZ, W; KALYANARAMAN, PS; RAMAKRISHNAN, G; et al. - JOURNAL OF ORGANIC CHEMISTRY Volume: 42 Issue: 13 Pages: 2264-2271 DOI: http://dx.doi.org/10.1021/
16. EUPATORIUM PERFOLIATUM - PLANT WITH A HISTORY
HALL, TB - MISSOURI MEDICINE Volume: 71 Issue: 9 Pages: 527-528 Published: 1974
17. STEROLS AND TRITERPENES FROM EUPATORIUM-PERFOLIATUM
DOMINGUE.XA; GONZALEZ.JA; PAULINOR.M - PHYTOCHEMISTRY Volume: 13 Issue: 3 Pages: 673-674 DOI: http://dx.doi.org/10.1016/
18. STUDIES OF BYRON BOG IN SOUTHWESTERN ONTARIO .38. INSECTS ASSOCIATED WITH FLOWERING BONESET, EUPATORIUM PERFOLIATUM L
JUDD, WW - PROCEEDINGS OF THE ENTOMOLOGICAL SOCIETY OF ONTARIO Volume: 99 Issue: SEP Pages: 65-& Published: 1968
19. Cell shape and cell volume relations in the pith of Eupatorium perfoliatum L
Marvin, JW - AMERICAN JOURNAL OF BOTANY Volume: 31 Issue: 4 Pages: 208-218 DOI: http://dx.doi.org/10.2307/
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